Two sample MR report

Telomere_length against IDP SWI T2star right putamen

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2614737	0.1384064	0.0727568
Weighted median	23	0.1789376	0.0659025	0.0066238
Inverse variance weighted	23	0.1298726	0.0541806	0.0165284
Simple mode	23	0.3157570	0.1405355	0.0350163
Weighted mode	23	0.1921700	0.0898697	0.0438470

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.34588	21	0.0117367
Inverse variance weighted	40.29441	22	0.0099864

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0080843	0.007826	0.3133506

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015398	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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