Two sample MR report

Telomere_length against IDP SWI T2star right pallidum

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2490013	0.1595800	0.1336206
Weighted median	23	0.0957187	0.0623257	0.1245920
Inverse variance weighted	23	0.0764817	0.0629095	0.2240830
Simple mode	23	0.0430098	0.1061131	0.6891568
Weighted mode	23	0.1116177	0.0727867	0.1394110

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	50.97492	21	0.0002665
Inverse variance weighted	54.32348	22	0.0001481

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0105979	0.0090232	0.2533345

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017565	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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