Two sample MR report

Telomere_length against IDP SWI T2star right hippocampus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0876679	0.1024287	0.4017183
Weighted median	23	-0.0000636	0.0581127	0.9991272
Inverse variance weighted	23	0.0535142	0.0400356	0.1813313
Simple mode	23	0.0066741	0.0991376	0.9469340
Weighted mode	23	-0.0197837	0.0856958	0.8195571

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.91709	21	0.7742915
Inverse variance weighted	16.04832	22	0.8134806

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020981	0.0057917	0.7207805

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005404	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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