Two sample MR report

Telomere_length against IDP SWI T2star right caudate

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3085438	0.1221464	0.0196405
Weighted median	23	0.1562927	0.0607738	0.0101197
Inverse variance weighted	23	0.0995034	0.0503379	0.0480743
Simple mode	23	0.2163835	0.1165388	0.0767879
Weighted mode	23	0.1464475	0.0796913	0.0796529

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.86483	21	0.0947380
Inverse variance weighted	34.78116	22	0.0408332

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0128414	0.0069066	0.0770537

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012411	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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