Two sample MR report

Telomere_length against IDP SWI T2star right amygdala

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1257868	0.1099273	0.2653865
Weighted median	23	-0.0754833	0.0625897	0.2278169
Inverse variance weighted	23	-0.0336556	0.0443915	0.4483592
Simple mode	23	-0.1101192	0.1366857	0.4290739
Weighted mode	23	-0.1438519	0.1649524	0.3925826

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.18877	21	0.2840024
Inverse variance weighted	27.04894	22	0.2093736

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0097947	0.0062157	0.1300198

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008411	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

Funnel plot

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Leave-one-out sensitivity analysis

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