Two sample MR report

Telomere_length against IDP SWI T2star right accumbens

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0042965	0.1024282	0.9669373
Weighted median	23	0.0972699	0.0576756	0.0916996
Inverse variance weighted	23	0.0955828	0.0400354	0.0169653
Simple mode	23	0.1341579	0.0999388	0.1931552
Weighted mode	23	0.1299281	0.0886711	0.1569907

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.83468	21	0.9143042
Inverse variance weighted	13.95699	22	0.9029988

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061356	0.0057916	0.3014553

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005957	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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