Two sample MR report

Telomere_length against IDP SWI T2star left thalamus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1301210	0.1139201	0.2662222
Weighted median	23	0.0595570	0.0546513	0.2758172
Inverse variance weighted	23	0.0328867	0.0443852	0.4587304
Simple mode	23	0.0220936	0.0863626	0.8004636
Weighted mode	23	0.0579534	0.0577243	0.3263086

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.97629	21	0.2073544
Inverse variance weighted	27.03994	22	0.2097135

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0059731	0.0064414	0.3643074

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008398	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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