Two sample MR report

Telomere_length against IDP SWI T2star left putamen

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2246750	0.1261579	0.0894002
Weighted median	23	0.0741872	0.0640755	0.2469418
Inverse variance weighted	23	0.0765125	0.0500095	0.1260268
Simple mode	23	0.1827101	0.1183582	0.1369236
Weighted mode	23	0.0941147	0.0784004	0.2427367

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.85834	21	0.0605116
Inverse variance weighted	34.32809	22	0.0454765

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0091016	0.0071334	0.2159153

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011509	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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