Two sample MR report

Telomere_length against IDP SWI T2star left pallidum

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2060876	0.1837158	0.2746222
Weighted median	23	0.1016069	0.0627381	0.1053310
Inverse variance weighted	23	-0.0124040	0.0728931	0.8648791
Simple mode	23	0.1133738	0.1067619	0.2997859
Weighted mode	23	0.0776751	0.0725415	0.2958805

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	67.56255	21	9e-07
Inverse variance weighted	72.93368	22	2e-07

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0134217	0.0103877	0.2103681

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0022124	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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