Two sample MR report

Telomere_length against IDP SWI T2star left hippocampus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0792695	0.1024289	0.4476167
Weighted median	23	0.0346253	0.0590184	0.5574148
Inverse variance weighted	23	0.0311146	0.0400357	0.4370575
Simple mode	23	0.1230734	0.0971103	0.2182791
Weighted mode	23	0.0509139	0.0778841	0.5200712

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.56217	21	0.8876616
Inverse variance weighted	13.82305	22	0.9076404

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029582	0.0057917	0.614846

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004372	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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