Two sample MR report

Telomere_length against IDP SWI T2star left caudate

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2388519	0.1101036	0.0416814
Weighted median	23	0.0499601	0.0571276	0.3818267
Inverse variance weighted	23	0.0426440	0.0456445	0.3501680
Simple mode	23	0.0069662	0.0883096	0.9378380
Weighted mode	23	0.0661860	0.0575332	0.2623325

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.26523	21	0.2803856
Inverse variance weighted	28.59632	22	0.1567510

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.012053	0.0062256	0.0664379

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009009	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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