Two sample MR report

Telomere_length against IDP SWI T2star left amygdala

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1640800	0.1024284	0.1241141
Weighted median	23	0.0075759	0.0569207	0.8941182
Inverse variance weighted	23	-0.0164097	0.0407796	0.6873894
Simple mode	23	-0.0994448	0.1047426	0.3527205
Weighted mode	23	-0.0237476	0.0726254	0.7467685

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.16027	21	0.5748594
Inverse variance weighted	22.82520	22	0.4116554

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0110874	0.0057916	0.0692931

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006968	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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