Two sample MR report

Telomere_length against IDP SWI T2star left accumbens

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0717637	0.1024284	0.4912291
Weighted median	23	-0.0031914	0.0584609	0.9564645
Inverse variance weighted	23	0.0108319	0.0400358	0.7867327
Simple mode	23	-0.0110439	0.0915234	0.9050497
Weighted mode	23	-0.0240677	0.0676229	0.7252977

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.28488	21	0.6936992
Inverse variance weighted	17.70256	22	0.7234704

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0037431	0.0057916	0.5250954

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005387	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8