Two sample MR report

Telomere_length against HippSubfield rh volume subiculum-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0457286	0.1210129	0.7093108
Weighted median	23	0.0007273	0.0671305	0.9913559
Inverse variance weighted	23	0.0105352	0.0463116	0.8200463
Simple mode	23	-0.0398736	0.1302449	0.7623740
Weighted mode	23	-0.0577435	0.1132810	0.6153118

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.12270	21	0.071640
Inverse variance weighted	31.27064	22	0.090709

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021609	0.0068394	0.7551623

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009498	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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