Two sample MR report

Telomere_length against HippSubfield rh volume subiculum-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2143182	0.1264382	0.1048459
Weighted median	23	-0.0031222	0.0659394	0.9622346
Inverse variance weighted	23	0.0390328	0.0508133	0.4423914
Simple mode	23	-0.0060952	0.1201124	0.9599860
Weighted mode	23	-0.0239766	0.0833592	0.7763217

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.97577	21	0.0364562
Inverse variance weighted	37.64565	22	0.0200712

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0107625	0.007146	0.1469395

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011713	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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