Two sample MR report

Telomere_length against HippSubfield rh volume presubiculum-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0205902	0.0994053	0.8379006
Weighted median	23	-0.0408475	0.0594511	0.4920339
Inverse variance weighted	23	0.0000946	0.0388452	0.9980560
Simple mode	23	0.0954147	0.1155034	0.4176295
Weighted mode	23	-0.0590490	0.0901201	0.5191155

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.33281	21	0.5002773
Inverse variance weighted	20.38391	22	0.5590388

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00127	0.0056182	0.8233396

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006177	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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