Two sample MR report

Telomere_length against HippSubfield rh volume presubiculum-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0043713	0.1272277	0.9729163
Weighted median	23	-0.0135254	0.0619444	0.8271588
Inverse variance weighted	23	-0.0719292	0.0489578	0.1417764
Simple mode	23	-0.1984957	0.1174667	0.1051885
Weighted mode	23	-0.0443392	0.0784475	0.5776508

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.40106	21	0.0328121
Inverse variance weighted	34.94620	22	0.0392494

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041481	0.0071906	0.5701603

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011627	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8