Two sample MR report

Telomere_length against HippSubfield rh volume parasubiculum

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0704829	0.0994059	0.4860967
Weighted median	23	0.0169773	0.0535139	0.7510535
Inverse variance weighted	23	0.0231389	0.0388454	0.5513976
Simple mode	23	0.0345226	0.0851277	0.6889981
Weighted mode	23	0.0456396	0.0616799	0.4671579

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.38827	21	0.5602478
Inverse variance weighted	19.65599	22	0.6045487

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029069	0.0056182	0.610277

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006064	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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