Two sample MR report

Telomere_length against HippSubfield rh volume molecular-layer-HP-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0089935	0.1223439	0.9420961
Weighted median	23	-0.0913393	0.0637399	0.1518578
Inverse variance weighted	23	-0.0358465	0.0467729	0.4434421
Simple mode	23	-0.0510817	0.1205845	0.6759576
Weighted mode	23	-0.1235633	0.0908896	0.1877644

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.81071	21	0.0611837
Inverse variance weighted	31.89684	22	0.0791719

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016488	0.0069146	0.8138451

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009923	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8