Two sample MR report

Telomere_length against HippSubfield rh volume molecular-layer-HP-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1999609	0.1267462	0.1295924
Weighted median	23	0.0144423	0.0592874	0.8075425
Inverse variance weighted	23	0.0350960	0.0506389	0.4882691
Simple mode	23	0.0523370	0.1092969	0.6367691
Weighted mode	23	0.0402319	0.0688107	0.5647147

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.14054	21	0.0350034
Inverse variance weighted	37.38695	22	0.0214433

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0101226	0.0071634	0.1722749

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011576	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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