Two sample MR report

Telomere_length against HippSubfield rh volume hippocampal-fissure

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0025409	0.1071573	0.9813062
Weighted median	23	0.0166769	0.0561075	0.7662907
Inverse variance weighted	23	0.0562313	0.0412559	0.1728860
Simple mode	23	0.0442928	0.0923980	0.6364068
Weighted mode	23	0.0002730	0.0595750	0.9963849

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.40246	21	0.2739696
Inverse variance weighted	24.81501	22	0.3060027

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036086	0.0060562	0.5576475

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008154	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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