Two sample MR report

Telomere_length against HippSubfield rh volume fimbria

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1149157	0.1108969	0.3118767
Weighted median	23	-0.0735962	0.0540326	0.1731755
Inverse variance weighted	23	-0.0562815	0.0426704	0.1871751
Simple mode	23	-0.0662360	0.0898176	0.4686419
Weighted mode	23	-0.0719857	0.0629787	0.2653186

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.13554	21	0.2013281
Inverse variance weighted	26.54616	22	0.2289727

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036001	0.0062676	0.5718003

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000868	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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