Two sample MR report

Telomere_length against HippSubfield rh volume Whole-hippocampus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1278896	0.1251601	0.3184994
Weighted median	23	-0.0015134	0.0632408	0.9809081
Inverse variance weighted	23	0.0203897	0.0487656	0.6758611
Simple mode	23	-0.0567254	0.1249275	0.6542288
Weighted mode	23	-0.0685999	0.1034832	0.5142752

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.29253	21	0.0430723
Inverse variance weighted	34.67285	22	0.0419032

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0066005	0.0070738	0.3613771

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001059	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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