Two sample MR report

Telomere_length against HippSubfield rh volume Whole-hippocampal-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0551715	0.1093728	0.6192073
Weighted median	23	0.0511792	0.0630577	0.4170069
Inverse variance weighted	23	0.0157104	0.0419099	0.7077638
Simple mode	23	-0.0285097	0.1283220	0.8262288
Weighted mode	23	0.0419947	0.1161290	0.7210853

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.42293	21	0.2293117
Inverse variance weighted	25.60892	22	0.2688512

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024229	0.0061815	0.6990365

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000781	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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