Two sample MR report

Telomere_length against HippSubfield rh volume Whole-hippocampal-body

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.1639728 0.1262417 0.2080666
Weighted median 23 -0.0417255 0.0608155 0.4926510
Inverse variance weighted 23 0.0246140 0.0498211 0.6212717
Simple mode 23 -0.0687165 0.1103230 0.5397759
Weighted mode 23 -0.0687165 0.0746360 0.3671993

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 33.87023 21 0.0374149
Inverse variance weighted 36.18991 22 0.0289730

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0085566 0.0071349 0.2437829

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0011088 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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