Two sample MR report

Telomere_length against HippSubfield rh volume Hippocampal-tail

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1886899	0.1528224	0.2305798
Weighted median	23	-0.0072901	0.0682455	0.9149303
Inverse variance weighted	23	0.0139752	0.0604511	0.8171739
Simple mode	23	0.1679492	0.1496024	0.2736948
Weighted mode	23	-0.0327661	0.0939195	0.7305009

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.63547	21	0.0004099
Inverse variance weighted	53.28152	22	0.0002075

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0107274	0.0086372	0.2279254

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016184	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8