Two sample MR report

Telomere_length against HippSubfield rh volume HATA

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1123699	0.1463233	0.4510631
Weighted median	23	-0.0318802	0.0593614	0.5912304
Inverse variance weighted	23	-0.0461451	0.0576780	0.4236830
Simple mode	23	-0.0910378	0.1147284	0.4359576
Weighted mode	23	0.0052663	0.0628133	0.9339417

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.50191	21	0.0014875
Inverse variance weighted	48.50308	22	0.0009307

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0097327	0.0082698	0.2524032

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015124	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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