Two sample MR report

Telomere_length against HippSubfield rh volume GC-ML-DG-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1087145	0.0994049	0.2864939
Weighted median	23	0.1333234	0.0588643	0.0235172
Inverse variance weighted	23	0.0754592	0.0388448	0.0520666
Simple mode	23	0.1319735	0.1140054	0.2594381
Weighted mode	23	0.1589743	0.1027031	0.1359121

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.92021	21	0.6540481
Inverse variance weighted	18.05230	22	0.7028832

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020419	0.0056182	0.7199074

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006614	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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