Two sample MR report

Telomere_length against HippSubfield rh volume CA4-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1409521	0.0994050	0.1708719
Weighted median	23	0.1395047	0.0588560	0.0177749
Inverse variance weighted	23	0.0834389	0.0388448	0.0317131
Simple mode	23	0.0209665	0.1142088	0.8560237
Weighted mode	23	0.1810494	0.1061813	0.1022587

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.49425	21	0.7412703
Inverse variance weighted	16.88933	22	0.7694403

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035313	0.0056182	0.5364189

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006516	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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