Two sample MR report

Telomere_length against HippSubfield rh volume CA4-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1618530	0.1209693	0.1952162
Weighted median	23	-0.0361973	0.0600293	0.5465125
Inverse variance weighted	23	0.0501379	0.0472787	0.2889282
Simple mode	23	0.0512566	0.1183321	0.6691163
Weighted mode	23	-0.0083114	0.0841533	0.9222194

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.10004	21	0.0720091
Inverse variance weighted	32.59070	22	0.0678681

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0068593	0.0068369	0.3271501

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001038	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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