Two sample MR report

Telomere_length against HippSubfield rh volume CA3-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0502409	0.0994065	0.6185357
Weighted median	23	0.0276751	0.0551892	0.6160485
Inverse variance weighted	23	0.0114136	0.0388454	0.7688951
Simple mode	23	0.0174259	0.0920373	0.8515661
Weighted mode	23	0.0318604	0.0693153	0.6502812

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.96185	21	0.8248611
Inverse variance weighted	15.14191	22	0.8560763

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002384	0.0056182	0.67564

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004615	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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