Two sample MR report

Telomere_length against HippSubfield rh volume CA3-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0878057	0.1106692	0.4364141
Weighted median	23	0.0382145	0.0592381	0.5188628
Inverse variance weighted	23	0.0460094	0.0424212	0.2781056
Simple mode	23	0.0388682	0.1051144	0.7150893
Weighted mode	23	0.0562367	0.0750786	0.4617689

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.02825	21	0.2053739
Inverse variance weighted	26.23690	22	0.2416499

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025663	0.0062548	0.685747

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008375	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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