Two sample MR report

Telomere_length against HippSubfield rh volume CA1-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0293645	0.1068919	0.7862221
Weighted median	23	0.0503755	0.0606558	0.4062483
Inverse variance weighted	23	0.0096998	0.0408492	0.8123056
Simple mode	23	0.0342546	0.1115361	0.7616431
Weighted mode	23	0.0613386	0.0914383	0.5093179

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.28240	21	0.2795778
Inverse variance weighted	24.32858	22	0.3302445

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012074	0.0060413	0.8435128

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007391	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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