Two sample MR report

Telomere_length against HippSubfield rh volume CA1-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1313888	0.1180136	0.2781460
Weighted median	23	0.0033568	0.0612000	0.9562581
Inverse variance weighted	23	0.0441956	0.0457422	0.3339500
Simple mode	23	-0.0253083	0.1150970	0.8279870
Weighted mode	23	-0.0142494	0.0747791	0.8506228

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.59827	21	0.1003629
Inverse variance weighted	30.50633	22	0.1066683

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0053537	0.0066699	0.4311609

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009636	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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