Two sample MR report

Telomere_length against HippSubfield lh volume subiculum-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0532292	0.1576922	0.7390520
Weighted median	23	-0.0110426	0.0623215	0.8593604
Inverse variance weighted	23	-0.0240467	0.0606105	0.6915577
Simple mode	23	0.0979596	0.1101594	0.3834876
Weighted mode	23	-0.0166742	0.0720903	0.8192225

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	52.84886	21	0.0001446
Inverse variance weighted	53.56212	22	0.0001895

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047448	0.0089124	0.6000547

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016344	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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