Two sample MR report

Telomere_length against HippSubfield lh volume subiculum-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1828485	0.1396503	0.2045679
Weighted median	23	-0.0080531	0.0646299	0.9008374
Inverse variance weighted	23	0.0386407	0.0548914	0.4814657
Simple mode	23	0.0884681	0.1199888	0.4687295
Weighted mode	23	0.0133213	0.0836542	0.8749308

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.44670	21	0.0049350
Inverse variance weighted	43.93058	22	0.0036181

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0088543	0.0078927	0.2745962

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013611	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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