Two sample MR report

Telomere_length against HippSubfield lh volume presubiculum-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0809377	0.1222191	0.5150233
Weighted median	23	0.0028961	0.0599172	0.9614494
Inverse variance weighted	23	-0.0198737	0.0475460	0.6759547
Simple mode	23	-0.0128152	0.1147823	0.9121148
Weighted mode	23	0.0243644	0.0791710	0.7611722

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.74582	21	0.0621100
Inverse variance weighted	32.95969	22	0.0624431

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0061898	0.0069076	0.3803598

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010067	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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