Two sample MR report

Telomere_length against HippSubfield lh volume presubiculum-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0621847	0.1285323	0.6335299
Weighted median	23	0.0766170	0.0606794	0.2067137
Inverse variance weighted	23	-0.0067931	0.0493286	0.8904688
Simple mode	23	0.0377331	0.1066117	0.7267605
Weighted mode	23	0.0801902	0.0839474	0.3498343

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.11212	21	0.0274454
Inverse variance weighted	35.47862	22	0.0345066

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034011	0.0072645	0.6444762

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010759	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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