Two sample MR report

Telomere_length against HippSubfield lh volume parasubiculum

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2926571	0.1090403	0.0138957
Weighted median	23	0.0810139	0.0583349	0.1649015
Inverse variance weighted	23	0.0290121	0.0479847	0.5454371
Simple mode	23	0.0901446	0.0988255	0.3715725
Weighted mode	23	0.0981053	0.0630718	0.1341073

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.26859	21	0.2357188
Inverse variance weighted	33.57076	22	0.0542837

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0161877	0.0061627	0.0157641

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010341	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8