Two sample MR report

Telomere_length against HippSubfield lh volume molecular-layer-HP-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0469044	0.1173595	0.6934398
Weighted median	23	-0.0602248	0.0556834	0.2794493
Inverse variance weighted	23	-0.0460385	0.0448070	0.3041921
Simple mode	23	-0.0007775	0.1082792	0.9943356
Weighted mode	23	-0.0576722	0.0667390	0.3968320

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.27139	21	0.1076369
Inverse variance weighted	29.27148	22	0.1372719

Test for directional horizontal pleiotropy

egger_intercept	se	pval
5.32e-05	0.0066329	0.9936804

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009295	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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