Two sample MR report

Telomere_length against HippSubfield lh volume molecular-layer-HP-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1250409	0.1396407	0.3806975
Weighted median	23	-0.1007464	0.0644634	0.1180885
Inverse variance weighted	23	-0.0297644	0.0551242	0.5892303
Simple mode	23	-0.1055349	0.1434030	0.4695462
Weighted mode	23	-0.1403582	0.0849095	0.1125251

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.44239	21	0.0049411
Inverse variance weighted	44.30485	22	0.0032480

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.009505	0.0078922	0.2418487

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013603	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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