Two sample MR report

Telomere_length against HippSubfield lh volume hippocampal-fissure

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0299750	0.0994055	0.7659670
Weighted median	23	0.0846897	0.0560619	0.1308791
Inverse variance weighted	23	0.0575212	0.0388452	0.1386648
Simple mode	23	0.0931410	0.1071469	0.3940775
Weighted mode	23	0.0498825	0.0713177	0.4916070

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.83601	21	0.4689975
Inverse variance weighted	21.75038	22	0.4748698

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053722	0.0056182	0.3498371

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007255	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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