Two sample MR report

Telomere_length against HippSubfield lh volume fimbria

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0825515	0.1147893	0.4799712
Weighted median	23	0.0205501	0.0585488	0.7255946
Inverse variance weighted	23	0.0138081	0.0442646	0.7550822
Simple mode	23	0.0881133	0.1122771	0.4409491
Weighted mode	23	0.0310956	0.0736222	0.6768562

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.00237	21	0.1400841
Inverse variance weighted	28.56679	22	0.1576496

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0042208	0.0064876	0.5223623

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008695	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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