Two sample MR report

Telomere_length against HippSubfield lh volume Whole-hippocampus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0818917	0.1400915	0.5650725
Weighted median	23	-0.0694538	0.0695286	0.3178316
Inverse variance weighted	23	-0.0309797	0.0544531	0.5694075
Simple mode	23	-0.1377556	0.1533680	0.3788027
Weighted mode	23	-0.1193154	0.1085921	0.2837576

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.71130	21	0.0045735
Inverse variance weighted	43.23305	22	0.0044170

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0069303	0.0079177	0.3913136

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013293	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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