Two sample MR report

Telomere_length against HippSubfield lh volume Whole-hippocampal-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0176212	0.1269498	0.8909271
Weighted median	23	0.0127712	0.0602813	0.8322164
Inverse variance weighted	23	-0.0370628	0.0487206	0.4468235
Simple mode	23	0.0911201	0.1032573	0.3870706
Weighted mode	23	0.0169592	0.0879679	0.8488931

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.25165	21	0.0340533
Inverse variance weighted	34.60883	22	0.0425472

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033576	0.0071749	0.6446311

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010762	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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