Two sample MR report

Telomere_length against HippSubfield lh volume Whole-hippocampal-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1260827	0.1438445	0.3906636
Weighted median	23	-0.1017877	0.0652312	0.1186621
Inverse variance weighted	23	-0.0115775	0.0563146	0.8371137
Simple mode	23	-0.1063424	0.1652602	0.5265614
Weighted mode	23	-0.1286333	0.0951146	0.1899850

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.97523	21	0.0023555
Inverse variance weighted	46.23876	22	0.0018423

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0084524	0.0081298	0.3103128

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014038	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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