Two sample MR report

Telomere_length against HippSubfield lh volume Hippocampal-tail

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1232468	0.1349415	0.3714338
Weighted median	23	-0.0468068	0.0610552	0.4433014
Inverse variance weighted	23	-0.0318289	0.0533974	0.5511241
Simple mode	23	-0.0127100	0.1291862	0.9225174
Weighted mode	23	-0.1232626	0.0917376	0.1927593

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.69996	21	0.0106571
Inverse variance weighted	41.57241	22	0.0070393

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0095216	0.0076266	0.2255958

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00128	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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