Two sample MR report

Telomere_length against HippSubfield lh volume HATA

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1648822	0.0994058	0.1120434
Weighted median	23	0.0118754	0.0587993	0.8399437
Inverse variance weighted	23	-0.0122878	0.0388453	0.7517548
Simple mode	23	-0.0132774	0.0980171	0.8934796
Weighted mode	23	0.0172208	0.0723451	0.8140556

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.87686	21	0.8290796
Inverse variance weighted	18.62592	22	0.6683002

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0108782	0.0056182	0.0664116

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005674	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8