Two sample MR report

Telomere_length against HippSubfield lh volume GC-ML-DG-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0137734	0.1003636	0.8921523
Weighted median	23	0.0503845	0.0573441	0.3795994
Inverse variance weighted	23	-0.0287918	0.0388450	0.4585747
Simple mode	23	0.0692381	0.1089797	0.5317664
Weighted mode	23	0.0549578	0.0871898	0.5349761

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.40712	21	0.4343344
Inverse variance weighted	21.62353	22	0.4825423

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026135	0.0056723	0.6497171

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006719	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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