Two sample MR report

Telomere_length against HippSubfield lh volume GC-ML-DG-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0591258	0.1436419	0.6847894
Weighted median	23	-0.0207509	0.0642645	0.7467722
Inverse variance weighted	23	-0.0179167	0.0552828	0.7458682
Simple mode	23	0.1478660	0.1310143	0.2712134
Weighted mode	23	-0.1078051	0.0945308	0.2663739

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.85056	21	0.0024446
Inverse variance weighted	44.55952	22	0.0030170

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047304	0.0081183	0.5663116

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013566	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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